Genetic lactase deficiency (LACT)
Intolerance to lactase can lead to strong intestinal dysfunction. This relatively common condition has a genetic origin namely a polymorphism in the gene coding for lactase, an enzyme responsible for the digestion of lactose.
Whole blood-based tests : 2 ml whole blood in EDTA tube. Keep at ambient temperature or 4°C. Stable for 48 hours. Do not freeze
In affected people, the production of the enzyme declines during or shortly after childhood, resulting in lactose malabsorption. Undigested lactose sugars affect the development of gut microflora, leading to dysbiosis. Two copies, or alleles, of the lactase gene are present in the genome. Each allele can be either type T (normal) or type C (abnormal).
A patient can have three possible genotypes:
- T/T: normal expression of the enzyme, patients are lactose tolerant
- C/T: only one functional copy which is sufficient for lactose metabolism, therefore these patients can be considered lactose tolerant
- C/C: these patients are lactase deficient, their tolerance to lactose is limited
Please kindly note that for all the tests that are done in our partner labs in the USA, a full prepayment must be received before your sample is sent for testing.
Partner labs demand a full prepayment before the sample can begin to travel. Thank you for your understanding and collaboration.
It will take approx. 4 weeks to get the results from all tests, except for MSA (6 weeks) and CD56 and CD57 (48 -72 hours).
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