Genetic lactase deficiency (LACT)
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Genetic lactase deficiency (LACT)

Intolerance to lactase can lead to strong intestinal dysfunction. This relatively common condition has a genetic origin namely a polymorphism in the gene coding for lactase, an enzyme responsible for the digestion of lactose.

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LACT: Request Form from EU

LACT: Request Form from USA

Whole blood-based tests : 2 ml whole blood in EDTA tube. Keep at ambient temperature or 4°C. Stable for 48 hours. Do not freeze

Description

In affected people, the production of the enzyme declines during or shortly after childhood, resulting in lactose malabsorption. Undigested lactose sugars affect the development of gut microflora, leading to dysbiosis. Two copies, or alleles, of the lactase gene are present in the genome. Each allele can be either type T (normal) or type C (abnormal).
A patient can have three possible genotypes:

  • T/T: normal expression of the enzyme, patients are lactose tolerant
  • C/T: only one functional copy which is sufficient for lactose metabolism, therefore these patients can be considered lactose tolerant
  • C/C: these patients are lactase deficient, their tolerance to lactose is limited
Data sheet
Do I need to prepay the test before receiving the kit?

No, we will send you an invoice once we receive your sample. All payment instructions are listed on the invoice. You can pay by wire transfer or credit card (VISA or Mastercard only). Please kindly note that checks are no longer accepted. The analysis report will be released only if the tests are paid.

What is the turnaround time for the tests?

Testing turnaround time is assay-dependent. Some results are available in 48h (like CD57 count, Phagotest, etc.), while some others need more time (like PCRs with sequencing confirmation). The results of analyses are delivered maximum 6 weeks after sample reception.

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