Polymorphisms of Vitamin D receptor (GVDR)
Bsm1 and Fok1 are two SNP's in the gene coding for VDR (vitamin D receptor).VDR is not only involved in skeletal metabolism but also in modulation of immune response, regulation of cell proliferation and differentiation. VDR dysfunction has been linked with osteoarthritis, cancer, diabetes and cardiovascular disease.
Whole blood-based tests : 2 ml whole blood in EDTA tube. Keep at ambient temperature or 4°C. Stable for 48 hours. Do not freeze
Fok1 is a T-C polymorphism. The T allele leads to a protein, which is less effective in transducing the vitamin D signal. This allele may be associated with certain cancers (ovarian cancer), as well as Crohn’s disease. According to Ruggiero’s abstract people with T allele have a lower response to GcMAF. People with C allele have a higher response. Heterozygotes will have a moderate response. Other Bsm1 is a C-T polymorphism. The C allele is associated with Th1 suppression and breast cancer, the T allele with SLE and RA. Therefore there may be a link between VDR polymorphism and Th1/Th2 balance.
Fok1:
C/C genotype: high responder (FF genotype)
T/C genotype: moderate responder (Ff genotype)
T/T genotype: low responder (ff genotype)
Bsm1:
C/C genotype: high responder (bb genotype)
T/C genotype: moderate responder (Bb genotype)
T/T genotype: low responder (BB genotype).
Please kindly note that for all the tests that are done in our partner labs in the USA, a full prepayment must be received before your sample is sent for testing.
Partner labs demand a full prepayment before the sample can begin to travel. Thank you for your understanding and collaboration.
It will take approx. 6 weeks to get the results from all tests, except for the Nagalase (5-6 weeks), the MSA (6-8 weeks), the FRAT test (8-10 weeks) and CD56 and CD57 (48 -72 hours).
feedback Report comment