Polymorphisms of Vitamin D receptor (GVDR)
Bsm1 and Fok1 are two SNP's in the gene coding for VDR (vitamin D receptor).VDR is not only involved in skeletal metabolism but also in modulation of immune response, regulation of cell proliferation and differentiation. VDR dysfunction has been linked with osteoarthritis, cancer, diabetes and cardiovascular disease.
Whole blood-based tests : 2 ml whole blood in EDTA tube. Keep at ambient temperature or 4°C. Stable for 48 hours. Do not freeze
Fok1 is a T-C polymorphism. The T allele leads to a protein, which is less effective in transducing the vitamin D signal. This allele may be associated with certain cancers (ovarian cancer), as well as Crohn’s disease. According to Ruggiero’s abstract people with T allele have a lower response to GcMAF. People with C allele have a higher response. Heterozygotes will have a moderate response. Other Bsm1 is a C-T polymorphism. The C allele is associated with Th1 suppression and breast cancer, the T allele with SLE and RA. Therefore there may be a link between VDR polymorphism and Th1/Th2 balance.
Fok1:
C/C genotype: high responder (FF genotype)
T/C genotype: moderate responder (Ff genotype)
T/T genotype: low responder (ff genotype)
Bsm1:
C/C genotype: high responder (bb genotype)
T/C genotype: moderate responder (Bb genotype)
T/T genotype: low responder (BB genotype).
No, we will send you an invoice once we receive your sample. All payment instructions are listed on the invoice. You can pay by wire transfer or credit card (VISA or Mastercard only). Please kindly note that checks are no longer accepted. The analysis report will be released only if the tests are paid.
It will take approx. 4 weeks to get the results from all tests, except for MSA (6 weeks) and CD56 and CD57 (48 -72 hours).
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