Cannabinoid receptors expression testing (CBR)
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Cannabinoid receptors expression testing (CBR)

Siniscalco et al. (J Autism Dev Disord. 2013; J Neuroinflammation 2014) reported that Cannabinoid receptor type 2 is up-regulated in peripheral blood mononuclear cells of children affected by autistic disorders and proposed CBR2 receptor as potential therapeutic target for the pharmacological management of the autism.

CBR: Request Form from EU

CBR: Request Form from USA

RNA-based tests : One TempusTM tube. Stable for 72 hours at ambient temperature. For longer periods freeze and ship at -20°C

Description

“Immune system dysregulation is well-recognized in autism and thought to be part of the etiology of this disorder. The endocannabinoid system is a key regulator of the immune system via the cannabinoid receptor type 2 (CB2R) which is highly expressed on macrophages and microglial cells. The mRNA level for cannabinoid receptor type 2 (CB2) was significantly increased in AD-PBMCs as compared to healthy subjects (mean ± SE of arbitrary units: 0.34 ± 0.03 vs. 0.23 ± 0.02 in autistic children and healthy subjects, respectively), whereas CB1 and fatty acid amide hydrolase mRNA levels were unchanged. mRNA levels of N-acylphosphatidylethanolamine-hydrolyzing phospholipase D gene were slightly decreased. The data from this study indicate CB2 receptor as potential therapeutic target for the pharmacological management of the autism care. GcMAF treatment was able to normalize the observed differences in dysregulated gene expression of the endocannabinoid system of the autism group.” (From : Siniscalco et al. J Autism Dev Disord. 2013; Siniscalco et al. J Neuroinflammation 2014).
This test is useful in case hemp oil therapy is envisaged.

Data sheet
Do I need to prepay the test before receiving the kit?

No, we will send you an invoice once we receive your sample. All payment instructions are listed on the invoice. You can pay by wire transfer or credit card (VISA or Mastercard only). Please kindly note that checks are no longer accepted. The analysis report will be released only if the tests are paid.

What is the turnaround time for the tests?

Testing turnaround time is assay-dependent. Some results are available in 48h (like CD57 count, Phagotest, etc.), while some others need more time (like PCRs with sequencing confirmation). The results of analyses are delivered maximum 6 weeks after sample reception.

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