CD38 ELISA test in serum
CD38, which has an important role in dendritic cells (DC) chemotaxis and migration to lymph nodes, was strongly up-regulated by LPS but practically not at all by Borrelia garinii (mostly inducing neuroborreliosis).
Serum-based tests : 2 ml SERUM. Centrifuge immediately after clotting. Keep at ambient temperature or 4°C for 24h. For longer periods, aliquot, freeze and ship frozen.
Borrelia garinii may affect crucial DC functions by blocking the up-regulation of important molecules in DC migration to lymph nodes, thus affecting further immune responses in Lyme borreliosis infection (Hartiala et al. 2007). Furthermore, to determine whether the inability of B. garinii to induce CD38 expression would be related to other B. burgdorferi genospecies as well, Hartiala and colleagues (J Immunol. 2010) stimulated DC with B. burgdorferi sensu stricto and B. afzelii. Neither of these Borrelia genospecies induced CD38 upregulation. Thus low levels of CD38 might indicate Borrelia infection. Thus low levels of CD38 would point towards Borrelia infection, while High levels of CD38 would suggest other Gram- bacterial infection(s).
No, we will send you an invoice once we receive your sample. All payment instructions are listed on the invoice. You can pay by wire transfer or credit card (VISA or Mastercard only). Please kindly note that checks are no longer accepted. The analysis report will be released only if the tests are paid.
It will take approx. 4 weeks to get the results from all tests, except for MSA (6 weeks) and CD56 and CD57 (48 -72 hours).
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