Methylation Cycle Polymorphisms (GFOL)
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Methylation Cycle Polymorphisms (GFOL)

677C-T and 1298A-C are two SNP's in the gene coding for MTHFR (methylene tetrahydrofolate reductase).The T allele of 677C-T, and the C allele of 1298A-C are the “bad” alleles, corresponding to a low activity form of MTHFR. The low activity leads to accumulation of homocysteine, and low levels of folate.

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GFOL: Request Form from EU

GFOL: Request Form from USA

Whole blood-based tests : 2 ml whole blood in EDTA tube. Keep at ambient temperature or 4°C. Stable for 48 hours. Do not freeze

Description

Results are reported as “high activity”, “moderate activity”, or “low activity”, corresponding to the following genotypes:

677C-T:
C/C genotype: high activity
C/T genotype: moderate activity
T/T genotype: low activity

1298A-C:
A/A genotype: high activity
A/C genotype: moderate activity
C/C genotype: low activity


The total activity of MTHFR depends on the combination of both SNP's. The worst is “low activity” on both.
MTHFR is involved in biological pathways related to DNA synthesis, DNA methylation (important for gene regulation), neurotransmitter synthesis, myelin synthesis and glutathione synthesis (important for detoxification and antioxidant activities). Folic acid itself, is a strong antioxidant.
There is a link between folate deficiency and cancer (notably prostate cancer) but benefits from folate supplementation in cancer is a controversial subject. Folate may prevent the appearance of cancer but since it is important for rapidly dividing cells (because it is needed for DNA synthesis) it could actually promote the growth of tumors, once they’re established.

Data sheet
Do I need to prepay the test before receiving the kit?

No, we will send you an invoice once we receive your sample. All payment instructions are listed on the invoice. You can pay by wire transfer or credit card (VISA or Mastercard only). Please kindly note that checks are no longer accepted. The analysis report will be released only if the tests are paid.

What is the turnaround time for the tests?

Testing turnaround time is assay-dependent. Some results are available in 48h (like CD57 count, Phagotest, etc.), while some others need more time (like PCRs with sequencing confirmation). The results of analyses are delivered maximum 6 weeks after sample reception.

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