Methylation Cycle Polymorphisms (GFOL)
677C-T and 1298A-C are two SNP's in the gene coding for MTHFR (methylene tetrahydrofolate reductase).The T allele of 677C-T, and the C allele of 1298A-C are the “bad” alleles, corresponding to a low activity form of MTHFR. The low activity leads to accumulation of homocysteine, and low levels of folate.
Whole blood-based tests : 2 ml whole blood in EDTA tube. Keep at ambient temperature or 4°C. Stable for 48 hours. Do not freeze
Results are reported as “high activity”, “moderate activity”, or “low activity”, corresponding to the following genotypes:
677C-T:
C/C genotype: high activity
C/T genotype: moderate activity
T/T genotype: low activity
1298A-C:
A/A genotype: high activity
A/C genotype: moderate activity
C/C genotype: low activity
The total activity of MTHFR depends on the combination of both SNP's. The worst is “low activity” on both.
MTHFR is involved in biological pathways related to DNA synthesis, DNA methylation (important for gene regulation), neurotransmitter synthesis, myelin synthesis and glutathione synthesis (important for detoxification and antioxidant activities). Folic acid itself, is a strong antioxidant.
There is a link between folate deficiency and cancer (notably prostate cancer) but benefits from folate supplementation in cancer is a controversial subject. Folate may prevent the appearance of cancer but since it is important for rapidly dividing cells (because it is needed for DNA synthesis) it could actually promote the growth of tumors, once they’re established.
Please kindly note that for all the tests that are done in our partner labs in the USA, a full prepayment must be received before your sample is sent for testing.
Partner labs demand a full prepayment before the sample can begin to travel. Thank you for your understanding and collaboration.
It will take approx. 4 weeks to get the results from all tests, except for MSA (6 weeks) and CD56 and CD57 (48 -72 hours).
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