Perforin expression assay (PERF)
Natural Killer cells (NK) are cytotoxic cells that mediate the immune response against certain cancer and virus-infected cells. NK cells are normally found in the peripheral blood and are classified by their cell surface markers such as CD3-/CD56+ cells.
RNA-based tests : One TempusTM tube. Stable for 72 hours at ambient temperature. For longer periods freeze and ship at -20°C
The activity of NK cells is altered in several disorders such as multiple sclerosis, lupus and CFS. The activity is very sensitive to various environmental pollutants. Since NK cells have a significant role in the defense against viruses, decreased NK activity can lead to the development of opportunistic viral infections. NK cells exert their cytotoxic effect by releasing perforin. Perforin is a protein that will destroy the cytoplasmic membrane of target cells and finally kill them. The expression of perforin mRNA can be measured as a mean to evaluate NK cell activation.
No, we will send you an invoice once we receive your sample. All payment instructions are listed on the invoice. You can pay by wire transfer or credit card (VISA or Mastercard only). Please kindly note that checks are no longer accepted. The analysis report will be released only if the tests are paid.
It will take approx. 4 weeks to get the results from all tests, except for MSA (6 weeks) and CD56 and CD57 (48 -72 hours).
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