Perforin expression assay (PERF)
Natural Killer cells (NK) are cytotoxic cells that mediate the immune response against certain cancer and virus-infected cells. NK cells are normally found in the peripheral blood and are classified by their cell surface markers such as CD3-/CD56+ cells.
RNA-based tests : One TempusTM tube. Stable for 72 hours at ambient temperature. For longer periods freeze and ship at -20°C
The activity of NK cells is altered in several disorders such as multiple sclerosis, lupus and CFS. The activity is very sensitive to various environmental pollutants. Since NK cells have a significant role in the defense against viruses, decreased NK activity can lead to the development of opportunistic viral infections. NK cells exert their cytotoxic effect by releasing perforin. Perforin is a protein that will destroy the cytoplasmic membrane of target cells and finally kill them. The expression of perforin mRNA can be measured as a mean to evaluate NK cell activation.
Please kindly note that for all the tests that are done in our partner labs in the USA, a full prepayment must be received before your sample is sent for testing.
Partner labs demand a full prepayment before the sample can begin to travel. Thank you for your understanding and collaboration.
It will take approx. 4 weeks to get the results from all tests, except for MSA (6 weeks) and CD56 and CD57 (48 -72 hours).
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