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Prostaglandin E2 ELISA test in serum (PGE2)
- PGE2 is a compound derived from membrane phospholipids.
- PGE2 is also a key mediator of immunopathology in chronic infections and cancer.
Serum-based tests : 2 ml SERUM. Centrifuge immediately after clotting. Keep at ambient temperature or 4°C for 24h. For longer periods, aliquot, freeze and ship frozen.
Description
- PGE2 enhances its own production but suppresses acute inflammatory mediators, resulting in its predominance at late/chronic stages of immunity.
- PGE2 selectively suppresses effector functions of macrophages and neutrophils and the Th1-, CTL-, and NK cell-mediated type 1 immunity, but it promotes Th2, Th17, and regulatory T cell responses.
- PGE2 modulates chemokine production, inhibiting the attraction of proinflammatory cells while enhancing local accumulation of regulatory T cells and myeloid-derived suppressor cells.
- Prostaglandin E2 (PGE2) has been found as significantly higher in autistic patients, recording an increase of 91.15% (El-Ansary & Al-Ayadhi, Lipids Health Dis. 2012).
- Furuyashiki, T. & Narumiya, S. Stress responses: the contribution of prostaglandin E2 and its receptors. Nat. Rev. Endocrinol. doi:10.1038/nrendo.2010.194.
- Narumiya S, Furuyashiki T. Fever, inflammation, pain and beyond: prostanoid receptor research during these 25 years. FASEB J. 2011 Mar;25(3):813-8. doi: 10.1096/fj.11-0302ufm. Review.
Data sheet
PGE2
Do I need to prepay the test before receiving the kit?
Please kindly note that for all the tests that are done in our partner labs in the USA, a full prepayment must be received before your sample is sent for testing.
Partner labs demand a full prepayment before the sample can begin to travel. Thank you for your understanding and collaboration.
What is the turnaround time for the tests?
It will take approx. 4 weeks to get the results from all tests, except for MSA (6 weeks) and CD56 and CD57 (48 -72 hours).
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