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Prostaglandin E2 ELISA test in serum (PGE2)
- PGE2 is a compound derived from membrane phospholipids.
- PGE2 is also a key mediator of immunopathology in chronic infections and cancer.
Serum-based tests : 2 ml SERUM. Centrifuge immediately after clotting. Keep at ambient temperature or 4°C for 24h. For longer periods, aliquot, freeze and ship frozen.
Description
- PGE2 enhances its own production but suppresses acute inflammatory mediators, resulting in its predominance at late/chronic stages of immunity.
- PGE2 selectively suppresses effector functions of macrophages and neutrophils and the Th1-, CTL-, and NK cell-mediated type 1 immunity, but it promotes Th2, Th17, and regulatory T cell responses.
- PGE2 modulates chemokine production, inhibiting the attraction of proinflammatory cells while enhancing local accumulation of regulatory T cells and myeloid-derived suppressor cells.
- Prostaglandin E2 (PGE2) has been found as significantly higher in autistic patients, recording an increase of 91.15% (El-Ansary & Al-Ayadhi, Lipids Health Dis. 2012).
- Furuyashiki, T. & Narumiya, S. Stress responses: the contribution of prostaglandin E2 and its receptors. Nat. Rev. Endocrinol. doi:10.1038/nrendo.2010.194.
- Narumiya S, Furuyashiki T. Fever, inflammation, pain and beyond: prostanoid receptor research during these 25 years. FASEB J. 2011 Mar;25(3):813-8. doi: 10.1096/fj.11-0302ufm. Review.
Data sheet
PGE2
Do I need to prepay the test before receiving the kit?
No, we will send you an invoice once we receive your sample. All payment instructions are listed on the invoice. You can pay by wire transfer or credit card (VISA or Mastercard only). Please kindly note that checks are no longer accepted. The analysis report will be released only if the tests are paid.
What is the turnaround time for the tests?
It will take approx. 4 weeks to get the results from all tests, except for MSA (6 weeks) and CD56 and CD57 (48 -72 hours).
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